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Antimicrobial therapy to eradicate asymptomatic carriage of C. In one study, metronidazole was not effective in eliminating carriage, and while vancomycin initially cleared the organism from stools, the rate of re-colonization was high at follow up 2 months later (169) often with new strains; one asymptomatic carrier developed CDI after vancomycin treatment.

Treatment of carriers also may increase the shedding of spores (170).