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Factors associated with prolonged symptoms and severe disease due to Clostridium difficile. Antimicrobial use and risk for recurrent Clostridium difficile infection. Prospective randomised trial of metronidazole versus vancomycin for Clostridium difficile -associated diarrhoea and colitis. A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile -associated diarrhea, stratified by disease severity.